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In trials, dose escalation may be delayed, reduced, or stopped according to protocol rules

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The cyclic lactam bridge between Asp and Lys side chains is retained, maintaining the conformational constraint that confers resistance to proteolytic degradation and stabilizes the His-D-Phe-Arg-Trp pharmacophore in its bioactive orientation

Rosiglitazone Rosiglitazone was marketed both alone (Avandia) (National Center for Biotechnology Information, 2023b) and combined with metformin (National Center for Biotechnology Information, 2023e) (Avandamet) or with glimepiride (National Center for Biotechnology Information, 2023d) (Avandaryl)

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